Human papillomavirus virus (HPV) genotype- and age-specific analyses of external genital lesions among men in the HPV Infection in Men (HIM) Study.
نویسندگان
چکیده
BACKGROUND Human papillomavirus (HPV) causes external genital lesions (EGLs) in men, including condyloma and penile intraepithelial neoplasia (PeIN). We sought to determine the incidence of pathologically confirmed EGLs, by lesion type, among men in different age groups and to evaluate the HPV types that were associated with EGL development. METHODS HPV Infection in Men (HIM) study participants who contributed ≥2 visits from 2009-2013 were included in the biopsy cohort. Genotyping by an HPV line-probe assay was performed on all pathologically confirmed EGLs. Age-specific analyses were conducted for incident EGLs, with Kaplan-Meier estimation of cumulative incidence. RESULTS This biopsy cohort included 2754 men (median follow-up duration, 12.4 months [interquartile range, 6.9-19.2 months]). EGLs (n = 377) were pathologically confirmed in 228 men, 198 of whom had incident EGLs. The cumulative incidence of any EGL was highest among men <45 years old and, for condyloma, decreased significantly over time with age. The genotype-specific incidence of EGL varied by pathological diagnoses, with high- and low-risk genotypes found in 15.6% and 73.2% of EGLs, respectively. Condyloma primarily contained HPV 6 or 11. While PeIN lesions primarily contained HPV 16, 1 PeIN III lesion was positive for HPV 6 only. CONCLUSION Low- and high-risk HPV genotypes contribute to the EGL burden. Men remain susceptible to HPV-related EGLs throughout the life span, making it necessary to ensure the longevity of immune protection against the most common causative HPV genotypes.
منابع مشابه
Re: Human Papillomavirus (HPV) Genotype- and Age-Specific Analyses of External Genital Lesions among Men in the HPV Infection in Men (HIM) Study.
متن کامل
Prevalence and Genotype Distribution of Human Papillomavirus in a Population of Iranian Men
Background and purpose: Human papillomavirus (HPV) often infects humans through sexual contact. Men are carriers of the HPV virus and inadvertently transmit the virus to their sexual partners while being asymptomatic. In many countries strategies are focused on controlling the virus in women and the role of men is ignored. The aim of this study was to determine the prevalence of HPV infection a...
متن کاملHuman papillomavirus genotypes in 108 patients with anogenital warts in a sexually transmitted disease clinic in Tehran
Background and Objective: Genital warts, the most common sexually transmitted disease (STD), are caused by human papillomavirus (HPV). Few studies have been performed on Iranian women with genital warts or cervix cancer but there isno documented data about genital warts and HPV genotyping in Iranian men. In this study, we determined HPV genotypesin 108 male and females with anogenital warts in ...
متن کاملAn analysis of HPV infection incidence and clearance by genotype and age in men: The HPV Infection in Men (HIM) Study
OBJECTIVES Genital HPV infection in men causes benign and cancerous lesions, the incidence of which differs by age. The goal of this work was to comprehensively evaluate incidence and clearance of individual HPV genotypes among men by age group. METHODS HIV-negative men ages 18-70 with no history of anogenital cancer were recruited for the HPV Infection in Men (HIM) Study. Participants comple...
متن کاملHPV-related external genital lesions among men residing in Brazil.
The aims of this study were to determine the incidence of external genital lesions (EGLs), specifically histologically confirmed condyloma (genital warts) and Penile Intraepithelial Neoplasia (PeIN), and genital HPV infection progression to EGLs among healthy men aged 18-73 residing in Brazil. Subjects included 1118 men enrolled in the HPV Infection in Men (HIM) study between July 2005 and June...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of infectious diseases
دوره 211 7 شماره
صفحات -
تاریخ انتشار 2015